Skip to Main Content

Advertisement

Newest Articles
Brief Definitive Report
Genki Okumura, Akiko Iguchi-Manaka, Rikito Murata, Yumi Yamashita-Kanemaru, Akira Shibuya, Kazuko Shibuya
This report demonstrated that soluble CD155 interferes with the DNAM-1mediated antitumor immunity mediated by NK cells and promotes lung colonization of B16/BL6 melanoma cells.
Brief Definitive Report
Roberto R. Ricardo-Gonzalez, Christoph Schneider, Chang Liao, Jinwoo Lee, Hong-Erh Liang, Richard M. Locksley
Activated ILC2s can enter circulation after migratory helminth infection. Using fate-mapping, alarmin-specific knockouts, and methods to isolate tissue-specific perturbations, the authors demonstrate that ILC2 extrusion from tissues reflects activation of pathways specific to receptors on the resident ILC2 population.
Article
Ivan Ting Hin Fung, Poornima Sankar, Yuanyue Zhang, Lisa S. Robison, Xiuli Zhao, Shanti S. D’Souza, Abigail E. Salinero, Yue Wang, Jiang Qian, Marcy L. Kuentzel, Sridar V. Chittur, Sally Temple, Kristen L. Zuloaga, Qi Yang
Fung et al. show that group 2 innate lymphoid cells (ILC2) accumulate in the choroid plexus (CP) of the aged brain. These aging-associated CP-resident ILC2 exhibit unique functional and molecular properties, and their activation revitalizes the aged brain and alleviates aging-associated cognitive decline.
Article
Juan Tang, Juan Tang, Sha Tu, Guoxin Lin, Hui Guo, Chengkai Yan, Qingjun Liu, Ling Huang, Na Tang, Yizhi Xiao, R. Marshall Pope, Murugesan V.S. Rajaram, Amal O. Amer, Brian M. Ahmer, John S. Gunn, Daniel J. Wozniak, Lijian Tao, Vincenzo Coppola, Liwen Zhang, Wallace Y. Langdon, Jordi B. Torrelles, Stanley Lipkowitz, Jian Zhang
Hyper-activation of NLRP3 inflammasomes contributes to the development of endotoxemia, but the molecular mechanisms are poorly defined. Tang et al. demonstrate that sequential ubiquitination of NLRP3 is crucial to keep NLRP3 inflammasomes in check and limits endotoxemia.
Brief Definitive Report
Jin Huk Choi, Xue Zhong, Zhao Zhang, Lijing Su, William McAlpine, Takuma Misawa, Tzu-Chieh Liao, Xiaoming Zhan, Jamie Russell, Sara Ludwig, Xiaohong Li, Miao Tang, Priscilla Anderton, Eva Marie Y. Moresco, Bruce Beutler
Choi et al. identify mice with a metabolic disorder and severe lymphoid and myeloid hypoplasia resulting from mutation of PDIA6. The ER-resident oxidoreductase PDIA6 is necessary for folding of stroma-derived Wnt3a, BAFF, and IL-7 proteins, which are necessary for hematopoiesis.
Article
Carsten Deppermann, Rachel M. Kratofil, Moritz Peiseler, Bruna A. David, Joel Zindel, Fernanda Vargas E Silva Castanheira, Fardau van der Wal, Agostina Carestia, Craig N. Jenne, Jamey D. Marth, Paul Kubes
Deppermann et al. investigate how aged platelets are removed from circulation. Using intravital microscopy they observe rapid accumulation of desialylated platelets on Kupffer cells through collaboration of macrophage galactose lectin and Ashwell-Morell receptor. Effective clearance is critical, as mice with an aged platelet population bleed.
Brief Definitive Report
Erin G. Reed-Geaghan, Andrew L. Croxford, Burkhard Becher, Gary E. Landreth
Fate mapping of resident microglia and peripheral monocytes reveals that the myeloid cells that migrate to and associate with amyloid plaques in a mouse model of Alzheimer’s disease are exclusively derived from resident microglia.

广西体彩网首页

Current Issue
Volume 217,
Issue 2,
February 3, 2020
Reviews & Opinions
Cytokines Focus Review
Leonie S. Taams
IL-17A is a rational therapeutic target in RA; however, clinical trials have shown relatively modest success. This review explores possible reasons for the limited clinical efficacy of IL-17A blockade in RA, guided by recent insights in IL-17 biology.
Insights
Simone Anfossi, George A. Calin
ncRNA-encoded polypeptide plays a big role in triple-negative breast cancer.
Insights
Miwa Sasai, Masahiro Yamamoto
Toxoplasma gondii ROP16 is a virulence factor that modulates immune reposes acting in cis and in trans.

广西体彩网首页

Advertisement

Tweets by @JExpMed

Special Collections

广西体彩网首页

A special collection of recent articles from JEM

View Collections
Close Modal
This Feature Is Available To Subscribers Only

Sign In or Create an Account

Close Modal
Close Modal
广西体彩网首页 | 下一页