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Joshua Titlow, Francesca Robertson, Aino J?rvelin, David Ish-Horowicz, Carlas Smith, Enrico Gratton, Ilan Davis
Local mRNA translation in neurons at a distance from the nucleus is key to new synapse formation. Titlow et al. find that the Syncrip RNA binding protein acts directly on msp300 mRNA to modulate activity-dependent synaptic plasticity. Single-molecule imaging reveals an activity-dependent increase in mRNP complex size and colocalization with ribosomes and the translation initiation factor eIF4E at the synapse.
Article
Katharina Haneke, Johanna Schott, Doris Lindner, Anne Kruse Hollensen, Christian Kroun Damgaard, Cyril Mongis, Michael Knop, Wilhelm Palm, Alessia Ruggieri, Georg Stoecklin
To ensure proper cell growth, the rates of proliferation and protein synthesis are tightly coupled. Haneke et al. demonstrate that the mitotic kinase CDK1 acts as an activator of global protein synthesis during all phases of the cell cycle.
Article
Brandt Warecki, Xi Ling, Ian Bast, William Sullivan
Cells dividing with late-segregating acentric chromosomes must reincorporate acentrics into telophase daughter nuclei to maintain euploidy. Here, Warecki et al. show that fusion between membrane on acentrics and membrane on daughter nuclei allows acentric passage through channels formed in all components of the nascent nuclear envelope, thus preserving genomic integrity.
Article
Michael A. Hadders, Sanne Hindriksen, My Anh Truong, Aditya N. Mhaskar, J. Pepijn Wopken, Martijn J.M. Vromans, Susanne M.A. Lens
Hadders et al. demonstrate that the kinases Haspin and Bub1 recruit separate pools of Aurora B to centromeres of human cells. Surprisingly, the Haspin- and Bub1-dependent pools of Aurora B do not control phosphorylation of important kinetochore substrates nor the mitotic checkpoint.
Amanda J. Broad, Keith F. DeLuca, Jennifer G. DeLuca
Broad et al. investigate multiple populations of Aurora B kinase at the centromere and kinetochore. Two distinct histone modifications initiate pathways that individually recruit Aurora B to spatially distinct centromeric regions, and neither pathway is required for localization or activity of Aurora B at kinetochores.
Article
Aaron P. van Loon, Ivan S. Erofeev, Ivan V. Maryshev, Andrew B. Goryachev, Alvaro Sagasti
Microridges, elongated 3D protrusions arranged in maze-like patterns on zebrafish skin cells, form by the accretion of simple precursor projections. Modeling and in vivo experiments showed that cortical contractions promote the coalescence of precursors into microridges by reducing surface tension.
Tools
Reika Tei, Jeremy M. Baskin
Tei et al. developed optogenetic phospholipase D enzymes for precisely generating the pleiotropic lipid second-messenger phosphatidic acid on specific organelle membranes and applied these tools to elucidate that a PM pool of phosphatidic acid can attenuate Hippo signaling.

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Current Issue
Volume 219,
Issue 2,
February 3, 2020
Reviews & Opinions
Review
Daniel Blumenthal, Janis K. Burkhardt
T cell activation requires force production at the immunological synapse. Blumenthal and Burkhardt describe how distinct actin structures contribute to this process, addressing canonical immunological models from a mechanobiology perspective.
Spotlight
Neel S. Singhal, Evan M. Lee, Dengke K. Ma
Singhal et al. highlight new findings from Schulz et al. regarding the survival-promoting effects of GDPGP1 in neural cells.
Spotlight
Linda Ma, Daniel A. Starr
Ma and Starr highlight new work from Rahman et al. that reveals new insight into the mechanisms controlling embryonic pronuclei fusion.

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